- GLA, ALA, Linoleic Acid and Oleic Acid
- Azelaic Acid, Vitamin B6 & Zinc
- Saw Palmetto
- Procyanidin Oligomers
Gamma Linolenic Acid, Alpha Linolenic Acid, and Linoleic Acid
In the studies that follow, it was found that the most powerful inhibitors of Type I and Type II forms of the enzyme 5-alpha reductase were Gamma Linolenic Acid (GLA), Alpha Linolenic Acid (ALA), and Linoleic Acid that were also highly effective in reducing DHT (dihydrotestosterone) levels on topical application. Moreover this was accomplished without causing any systemic effects.
Additionally, studies reveal that these fatty acids are effective in the treatment of DHT related disorders that include acne, male pattern hair loss and excessive female body hair (hirsuitism).
Topical application of GLA and other fatty acid inhibitors of the enzyme 5 alpha-reductase suppressed growth of hamster flank organs.
Androgen action: molecular mechanism and medical application.
Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids